Loop diuretics are widely used, especially in patients with hypertension or heart failure plus renal dysfunction. Such patients are particularly susceptible to untoward drug effects. It is, therefore, ...

In a transformative new paper, Alex Gillespie and Brady Wagoner extend the concept of “looping effects,” originally introduced by philosopher Ian Hacking to describe the two-way relationship between ...

The vertebrate body plan is overall symmetrical but left–right (LR) asymmetric in the shape and positioning of internal organs. Although several theories have been proposed, the biophysical mechanisms ...